Tag: virology

  • Varicella-Zoster Strikes Again

    Shingles on day 3, 6, and 11
    Shingles on day 3, 6, and 11

    I had chicken pox when I was 8 years old. This was before there was a vaccine for varicella zoster, the virus that causes chicken pox. When I was growing up everyone got the virus and it made you feel like crap and gave you sores all over (most people wound up with at least a few scars) and then you got better. In fact, when the vaccine was introduced in 1995 many people thought it wasn’t necessary because the disease was relatively mild. The 10,000 people hospitalized each year in the US because of complications and 100 people who died every year probably didn’t agree.

    And you know what? I don’t agree either. Varicella or Herpes zoster is a tricky virus that goes latent in nerve cells, much like its cousin Herpes simplex virus. Basically this means that when you recover from your infection, some virus hides out, waiting for your immune system to get weak from stress, old age, other infections, or whatever and then it attacks again! I don’t know what triggered it in my case, but a few days ago I got shingles. Shingles is a yucky, sometimes terribly painful, outbreak of the same virus that causes chicken pox. This time I didn’t get a fever and sores all over, just a cluster of sores along one of the nerves on my back. The scary thing about this, though, is that I am infectious. I could actually give chicken pox to someone who hasn’t had a chance to be vaccinated (a newborn baby for example), a pregnant woman, or anyone who is immunocompromised for some other reason like HIV disease or because they’ve had a transplant.

    I could also give chicken pox to people whose parents chose not to vaccinate them. These could be children or adults. Unfortunately, they didn’t get a chance to decide whether they wanted to get a life threatening illness because their parents thought it would be “healthier” than getting a vaccine. They also won’t get to choose when they get shingles, and will put other completely helpless populations at risk when they get infected.

    Some anti-vaccine people perpetuate the myth that being infected and recovering from a natural infection provides better immunity than getting a vaccine. This is simply not true. Viruses have evolved sly ways of manipulating our immune system, and often the immunity you develop from natural infections will not protect you very well from being reinfected or from the reactivation of latent viruses.

    You know, if I had been born a decade later, I would have been able to get the chicken pox vaccine and I wouldn’t have this icky rash on my back. If I were older, my doctor would have recommended the shingles vaccine for me.  Unfortunately I am stuck in the middle and got sick, but you don’t have to.  Go get the varicella vaccine, and get your children vaccinated.

  • The movie “Contagion” is so realistic it’s boring

    I have been looking forward to seeing the movie Contagion since it came out last year and I finally got to see it last night. I am a big fan of outbreak/apocalypse/zombie-type movies and, since I’m an immunologist, I thought this would be right up my alley. Boy, was I wrong. The problem with the movie wasn’t with the premise (a new flu-like virus makes the jump from an animal reservoir to humans and starts spreading rapidly), the casting (Gwyneth Paltrow, Matt Damon, Jude Law, Kate Winslet, Laurence Fishburne), or the science (mostly spot on). The problem was that the movie was way too realistic.

    Hmmm, let’s see, we’ve got politicians and public health officials trying to keep the public from freaking out, a corrupt blogger/homeopathic proponent trying to get people to take an herbal remedy to recover from the virus (while he’s invested in the company that makes it), a protective father/widower (Matt Damon better watch out or he’s going to be typecast soon!), mass riots and looting, a dedicated scientist who makes a vaccine in no time, and the ultimate recovery of the country and the economy.

    Wait, huh? Where are the zombies? Where are the ghost towns? Where’s the blood oozing from eyeballs? This is just like what would happen in real-life if a virus wiped out 1% of the population of the Earth. People would be scared. People would lose loved ones. People would get sick and recover and then we’d move on. I don’t need a movie for this! There are way more dramatic things happening in the world right now! I think some character development could have saved the movie, but there were so many story lines going on at the same time it was impossible to get invested in any one character and the story lines never really converged.

    SCIENCE CRITIQUE: the screenwriters of contagion mostly did a good job with getting the science right and the set designers made things look pretty good. Only a few things stuck out. In one scene they were rotating a ribbon diagram of what was supposed to be the virus and its human receptor and they were describing four proteins, but it only looked like there were two on the screen.  It also didn’t make a lot of sense that Kate Winslet’s character, a CDC EIS officer, was explaining basic epidemiology to a group of state health department officials (don’t they have degrees in public health?). But the labs looked good and the CDC really looked like the CDC (although I’ve never been in a BSL4 lab).

    The bottom line: see the movie if you want a preview of what the next terrible outbreak will be like, but stay away if you’re looking for zombies …